UK registered pharmacy
UK licensed treatments
Trusted by over 1.5 million people
Melatonin information
Melatonin is a natural hormone that our body releases after the onset of darkness. It makes people feel sleepy and it helps to regulate the body’s circadian rhythm.
Melatonin is licensed for the treatment of jet lag and it has been found to be particularly effective in those travelling eastwards.
It can also be used short-term in people aged 55 and over, who find it difficult to get to, or to stay, asleep.
Melatonin is a Prescription Only Medicine (POM) and cannot be bought over the counter.
Melatonin should not be taken by anybody with a hypersensitivity to any of the ingredients. It is not recommended for use in those with an autoimmune disease. Melatonin should be used with caution in people with renal or liver impairment and you should speak to your doctor before use as its use is not recommended. Melatonin interacts with various medicines and you should discuss with your doctor before use if you are taking other medications. Some of the medicines that can interact with Melatonin include fluvoxamine, contraceptive or hormone replacement therapy oestrogens, quinolones, carbamazepine, and rifampicin.
The usual dose is one 3mg tablet to be taken by mouth after food, 1 to 2 hours before bedtime. Tablets should be swallowed whole with a glass of water. Do not chew or crush.
It should not be taken before 8pm or after 4am in the time zone that you are in and should not be taken for more than 5 days in a row.
If one tablet is ineffective, the dose can be increased to a maximum of two 3mg tablets (6mg).
Side effects with melatonin are uncommon.
Melatonin can cause drowsiness, so it is important not to drive or operate machinery within 8 hours of taking it.
Recent studies have suggested melatonin may increase the risk of falls, accidents, memory disturbance, dependence and withdrawal symptoms and an increased risk of dementia.
In addition, melatonin can cause anxiety, fatigue, dry mouth, abdominal discomfort, a rise in blood pressure and mood changes.
Very rarely, melatonin has been associated with aggression, muscle complaints, seizures, urinary problems and vomiting.
Always read the label of any medication that you take and only take according to the instructions provided. Do not exceed the stated dose.
Always read the patient information leaflet before commencing treatment.
View patient information leaflet.85,000+ verified customer reviews
“Impressively quick service”
Impressively quick service. Easy site to navigate and meds delivered by reliable Royal Mail, so well pleased. Thank you!
“My full 5 star approval”
Great service, easy to navigate the questionnaire and far quicker service than waiting for the NHS services to approve and dispense your meds. Completely legitimate products, unlike so many other bogus sites. I have placed a couple of orders, even today, a Saturday, with estimated delivery this Monday. Awesome! This company has my full 5 star approval.
“Excellent service from the start”
Full information, quick delivery, follow up email. Professional would not purchase from anyone else.
“Very happy”
Fantastic service and very fast delivery, very happy with this service.
“Very fast delivery”
Very fast delivery, I am happy with the speed that I got to order what I needed and fast delivery, really needed to start taking the product. Thank you.
“Infinitely quicker”
Such an easy way to get medication quickly. Superb service and quick delivery. I couldn’t even get through to my Drs so although this costs a bit more it’s infinitely quicker.
“No hassle”
Fantastic and quick response, no hassle trying to get a doctor appointment, thanks MedExpress.
“I highly recommend them”
I have used them many times & the procedure is very easy & the delivery very quick.
“This is a brilliant service”
This is a brilliant service and so quick and efficient. I would have had to wait god knows how long for a GP appointment for this medication.
“Aftercare very good”
Checked properly by a doctor before medication was prescribed and aftercare very good. Received yesterday kept up to date with the delivery and had to sign for which I like so there’s no missing parcel. Highly recommended.
“I would recommend!”
Trustworthy, professional and speedy delivery service. I have used this pharmacy a few times and I would recommend!
How it works
Answer quick questions
No GP or pharmacy visits, just a quick online consultation.
Get approved by our doctors
Our medical team will review your answers and approve.
Receive your treatment
Your treatment arrives in discreet packaging, delivered to your door.
Delivery options
Usually delivered the next working day
Guaranteed next working day by 1pm
Guaranteed next working day by 9am
Usually collection next working day
Backed by our experienced UK-based medical team
Dr Bryony Henderson
Dr. Bryony Henderson joins HeliosX as Medical Director for the UK and US, bringing extensive clinical operations, governance, and digital health experience from Kry/Livi and Numan. A recognised clinical voice, she has contributed to award-winning campaigns, published on health inequalities, and appeared across major national media. At HeliosX, she leads clinical governance and quality and supports the delivery of safe, innovative, scalable care.
Dr Adam Abbs
Adam is a doctor and advocate for increasing access to healthcare internationally. He has extensive experience in video consultations, technology-enabled examinations, remote biomarker testing, and education. He is a published author and has medical licenses in the UK, Spain and Republic of Ireland.
Dr Safia Hussain
Consultant GP and Quality Lead
MBBS, BSc, MRCGP, DRCOG, PGDip Clinical Dermatology
Safia is a GP with experience working in the NHS with a particular interest in diabetes and weight loss management. She is passionate about the power of digital healthcare and oversees our approach to patient safety and regulatory compliance.
Declan Lismore
Declan is a pharmacist with 15 years of experience and is passionate about digital healthcare. He has extensive experience across all pharmacy sectors in the UK and Ireland. He has led the clinical and regulatory functions of some of the biggest pharmacy organisations in the UK and is excited about the future of the industry.